Image of REPLENIX Caffeine Fortified Calming Serum | Sensitive | Medical Grade Skincare Caffeine Fortified Calming Serum $102.00

Caffeine Fortified Calming Serum

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Avoiding eye area, apply to clean face and neck once or twice daily or as directed by your doctor. For topical use only.

Reduce redness, moisturize, and protect skin's barrier with REPLENIX Caffeine Fortified Calming Serum.

(formerly known as REPLENIX Serum CF Caffeine Enhanced)

REPLENIX Caffeine Fortified Calming Serum is scientifically formulated to be ultra-calming to the skin. This advanced serum is fortified with medical-grade Caffeine USP and our proprietary Green Tea Polyphenol Technology to provide a powerful dose of antioxidants while visibly reducing redness. Skin feels cool and calm as it’s infused with moisture while skin’s barrier is protected from damaging free radicals.

Purified Water, Caffeine, 90% Polyphenol Isolate of Camellia Sinensis (Green Tea) Leaf Extract, Hyaluronic Acid, Bisabolol, Cucumis Sativus (Cucumber) Fruit Extract, Chamomilla Recutita (Matricaria) Flower Extract, Triethanolamine, Polysorbate-20, Carbomer, Methylparaben, Diazolidnyl Urea, Tetrasodium EDTA

Understanding our role in creating a better tomorrow for healthy skin to thrive in, we're committed to a multi-faceted approach of progressive carbon footprint reduction, inclusive of responsibly-sourced raw materials, reduced secondary packaging and recyclable products.


Customer Reviews

Based on 17 reviews
Heather O. (Fontana, CA, US)
Age: 35 - 44
Skin Type: Sensitive
Skin Concern: Rosacea, redness or eczema
Good product

I haven’t been using this very long, but so far I love it. I am OBSESSED with Replenix neck cream and the results it has given me, so I look forward to seeing more change as I use this. So far it seems like it has really calmed down my rosacea flairs, which is huge. I recommend!

Jilan Liu (West Lafayette, IN, US)
Age: 25 - 34
Skin Type: Combination
Skin Concern: Anti-aging and prevention
Good texture for absorbing!

The serum has a smooth and easy-absorbing texture. Really soothe your skin!

Nancy Clark (Winston-Salem, NC, US)
Age: 55+
Skin Type: Dry
Skin Concern: Anti-aging and prevention

Great product for keeping your face feeling moisturized and nourished.

Anqina Zou (Roseville, CA, US)
Age: 25 - 34
Skin Type: Oily
Skin Concern: Blemishes and breakouts
Caffeine Fortified Calming Serum

My all time favorite serum forever!

juan (Stockton, CA, US)

Dear Replenix Team,

I am writing to inquire about the authenticity of a partnership between your company and a seller on the Chinese online shopping platform Taobao. As a customer of your products, I recently discovered a store on Taobao that claims to sell your products, with nearly 300,000 subscribers and prices at 60% off the rates on your official website in the US. I am concerned about whether this seller is an authorized partner of your company and whether the products being sold are genuine.

The name of the store is [Replenix 海外旗舰店], and the product I am particularly interested in is the "cf" series. Currently, the price of the "cf" essence on your official website is $90 USD before tax, while it is being sold for ¥465 RMB on the Chinese platform. This translates to approximately $66 USD after tax.

As your loyal customer, I would greatly appreciate it if you could confirm whether this seller is a legitimate partner and whether the products being sold are genuine Replenix products.

Thank you for your attention to this matter, and I look forward to your reply.


Pee Vee

I have finicky, reactive skin. I hesitate to use the word sensitive, since I bet most people think their skin is sensitive! But, my skin lets me know very quickly, generally with red spots, if it doesn't like a product. This serum is lovely! Calms my skin and there has been no adverse reaction whatsoever. I also have fairly oily skin and I live in north Florida. This serum soaked right in and did not leave my skin shiny. So, no smell, no reaction, and no greasy feel. Does it do anything though? Yes! My skin looks great--I am 64 and looking for an antioxidant product that works, that doesn't break the bank, that doesn't go rancid, and that works. I think I found it!

Great for combined skin

Happy with this product, it works to control oil during the day and reduce redness, keep your makeup stay good all day long!


Very watery but does not keep hydrated for long; Does not see an effect for antioxidant for now.

Absolutely A Winner!

This is a wonderful product even for sensitive skin which I have along with rosacea, it's very hard for me to find a skin care line for my sensitive skin and rosacea but so far this skin care line has been wonderful in controlling my redness due to rosacea! I switched from Rodan & Fields to this line because it for some reason stopped working for me. So definitely 5 stars for this product and the Gentle skin care line by Replenix. I'm very happy with it.

will buy again