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Hyaluronic Acid Hydration Serum

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$92 1 oz.

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"This product is a game-changer! It's so silky smooth, absorbs nicely into the skin, and the hydration is instant! It's my face's new best friend!!​​"

(formerly known as REPLENIX Pure Hydration Hyaluronic Acid Serum)

REPLENIX Hyaluronic Acid Hydration Serum is an intensely pure, medical-grade, ultra-hydrating serum with fractionated hyaluronic acid that quenches dehydrated, dull skin for a supple, smooth, plump-looking complexion. Visibly reducing the signs of aging, skin appears brighter, firmer, and rejuvenated as skin’s barrier is protected from damaging free radicals.

​Avoiding eye area, apply to clean face and neck once or twice daily or as directed by your doctor. May also be applied to other dry skin areas including hands, elbows, and feet. For topical use only. This universal booster may be added to your favorite Replenix cream or serum for enhanced hydration.

Reduce the signs of aging and protect skin's barrier from free radical damage with REPLENIX Hyaluronic Acid Hydration Serum.

Fractionated Hyaluronic Acid:  Featuring both short and long-chain molecules for maximum penetration and absorption, this medical-grade, naturally occurring ingredient in the skin retains water on the skin’s surface forming an advanced protective barrier to seal in vital moisture and protect skin’s barrier.

Palmitoyl Tripeptide 28: This highly advanced peptide supports healthy collagen production, improving elasticity and firmness of the skin.

Proprietary Blue Copper Complex: An advanced medical-grade complex to help moisturize and condition skin while reducing excess oil. Naturally blue in color and free of artificial dyes.


Purified Water, Glycerin, Sodium PCA, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Camellia Sinensis (White Tea) Extract, Palmitoyl Tripeptide-28, Erothioneine, Glutathione, Zinc PCA, Copper PCA, Phenoxyethanol, Disodium EDTA

Customer Reviews

Based on 171 reviews
So worth it!!

Replenix Hyaluronic Acid was recommended to me by my Dermatologist after I had an IPL and Fraxel done on my face. It helped my healing process tremendously. It is a wonderful product - makes my face smooth, pores smaller and overall better skin texture. Not sticky - like some I have tried. Worth the price!

Wonderful serum, AWFUL dispenser

I've used this serum for years as it's very, very helpful it you use Retinol. I absolutely detest the new packaging. The dropper is awful, you can't see how much serum you have on hand. You DC'd two of my favorite products and made the last one unusable. I'll not buy this again in this packaging. What were you thinking? I hate form over function. UGH!


Love this product, non irritating, came beautifully packaged…?

Love it!

This is a great serum. It feels silky, and goes on smooth. I noticed results instantly. It just makes my face feel hydrated and will definitely be staple for me especially heading into the winter.

Excellent hydration, dropper could be better

I tried the sample and loved it ever since. Sometimes I dont feel like the dropper grabs enough product. I have to try at least twice. Made me wonder if the bottle was even filled completely. But I do love the serum it's very hydrating

I would buy again

Best on the market

I love

It's so hydrating and makes my skin look so dewy

A must for my skin regimen

I use HA twice a day. It keeps my face moist. Try it, you will live it!!

Love this product

Just started using for the first time and it feels wonderful and goes on smoothly

Great hydration, so-so applicator

I love the feel of this serum & the legit hydration. I also use the Vitamin C serum (first) and feel the dropper applicator works better for that product. After a few tries I've learned to squeeze the top before untwisting it; this draws up the most product into the tube. The consistency is more gel-like than the Vit C, but even that small amount smooths across my face easily. Love, and certain to reorder!