24-Hour Skincare Collection

Retinol 5x Regenerate Dry Serum

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$88 1 oz.

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(formerly known as REPLENIX Retinol 5x Regenerate Dry Serum)

​REPLENIX Retinol 5x Regenerate Dry Serum is a powerful skin-regenerating dry serum scientifically formulated to help reduce the appearance of fine lines, wrinkles and achieve smoother, firmer, more evenly toned skin. This clinically proven retinol serum pairs a proprietary, patent-pending delivery system with our advanced proprietary Green Tea Polyphenols Technology to efficiently deliver retinol into skin without any irritation and allowing skin to return to its natural calm state.

​Avoiding eye area, apply 3-4 pumps to clean skin once a day, in the evening, or as directed by your physician. Speak with your physician before using if pregnant.

Reduce the appearance of fine lines and wrinkles with ​REPLENIX Retinol 5x Regenerate Dry Serum.

Proprietary Skin-Regenerating Duo with Advanced Delivery System​:

  • All-Trans Retinol: A medical-grade, highly advanced, and stable retinol, it works to help support cellular turnover to reduce the appearance of fine lines, wrinkles, and age spots, promoting a plump, collagen-rich appearance.​
  • Proprietary Green Tea Polyphenol Technology: Proven to be the most powerful and effective antioxidant - and now purified to its highest form with the most advanced proprietary delivery system - this powerhouse green tea technology works instantly to soothe and calm irritated skin while providing superior anti-aging protection from damaging free radicals.

Caffeine USP:  This ultra-purified, clinical-grade antioxidant enhances overall antioxidant activity to maximize protection against free radicals while helping to diminish the appearance of redness and irritation.

Cyclopentasiloxane, Caprylyl Methicone, Dimethicone Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Disiloxane, Caffeine, PEG/PPG-18/18 Dimethicone, Camellia Sinensis (Green Tea) Polyphenols, Retinol, Sodium Hyaluronate, Polysorbate 20, Cyclomethicone

Customer Reviews

Based on 12 reviews
Replenix Retinol

So far this product has been awesome! I love the way it feels on my skin and my skin already looks so much healthier after only a few weeks of using it.

Feels great

Just switched to this product after a friend suggested it and love it so far!! Feels great on my skin. Very smooth and does not dry me out like other retinol products have in the past.

Nighttime Must Have!

Love this product!!! I find that Retinol products work well for my skin, this one has been my favorite by far. I love the consistency and I notice my skin is smother, more even, and fine lines are visibly diminished.


This product Really works well! It Gets the job done without causing irritation on your face. I use it every day.

Wonderfully smooth texture .....

I am 77 yrs. old, and have been using Obagi Nu-Derm for 20 yrs. At night I use their Blender plus their .10% cream. But in the AM I have only used their Clear and Exfoderm. Now I put on with them the Replenix over them and I love how it makes my skin feel .... smooth and not sticky. And I think with the added benefit of the Replenix in the AM my skin looks better still. I'm very pleased. Folks think I'm in my 50's .... can't beat that!!!! BB

Feels great

One of the best retinols I've used

Retinol X5

I really love this consistency! I am finding I have had a few breakout since using the product which is annoying BUT I know this is normal when skin care is really working!

Amazing product

I've been using this product for years. I am not sure if there is a change on formulation with the new package, but it continues to work well with my skin. The product feels like silk and I do not feel any discomfort, even though I have sensitive skin.

Lightweight and gentle

I love retinols for its anti aging properties. I found this retinol to be very lightweight and gentle on the skin. I use a pea size amount for my entire face and experienced no purging, redness or irritation. It could be a bit more hydrating, but I know retinols in general are more on the dry side. I think oily skintypes would like this for its soft matte finish. May pill a bit if you have super dry skin though so make sure you hydrate with a toner or serum first

Good for beginners

This retinol is perfect if you are younger and just starting to get into retinols. It has a putty like consistency which can be off putting at first. It feels thick as you apply it, BUT it is because this retinol is meant to stay on the skin and to keep depositing that retinol into the skin throughout the day. Honestly its one of the best retinols I've used. I can tell my fine lines are not as prevalent. Would recommend to start here!